The Quarter-Final tie will be played on Tuesday, 15 November and carries a 7:45pm kick-off.
Ticket arrangements are not yet in place, but it is envisaged only the Merton Stand Blocks A, B, C and D will be open.
Holme Lacy FC currently lie in 5th place in the Herefordshire FA Premier Division, two points behind league leaders Tenbury United but have played four more games than many of their rivals.
Orleton Colts were narrowly beaten 1-0 last Saturday, with Lacy at home to Ewyas Harold tomorrow afternoon.
The HFA County Challenge Cup, Quarter-Final draw in full:
Hereford FC v Holme Lacy FC – Tuesday, 15 November
Bromyard v Pegasus Juniors – Wednesday, 9 November
Leominster Town v Hereford Lads Club – Wednesday, 16 November
Kington Town v Westfields FC – Tuesday, 20 December